Table 3. Effects of YOBH on hindlimb weight-bearing distribution in MIA-induced osteoarthritis rats
| Group | Hindlimb weight-bearing distribution (%) |
| Days after MIA injection |
| 7 | 12 | 17 | 22 | 27 | 32 |
| NC1) | 100.00±7.572) | 100.00±7.90 | 100.00±4.47 | 100.00±3.88 | 100.00±3.34 | 100.00±1.64 |
| OAC | 52.90±6.07*3) | 59.29±3.83* | 59.62±5.04* | 59.74±6.15* | 54.21±5.72* | 57.19±7.74* |
| YOBH 500 | 54.35±11.14 | 58.62±14.70 | 59.15±11.15 | 62.35±13.21 | 58.93±12.32 | 62.36±9.03 |
| YOBH 1,000 | 59.60±5.62 | 65.36±5.38#2) | 67.87±4.42# | 69.04±4.41# | 70.12±5.70# | 66.77±12.61 |
| YOBH 2,000 | 62.53±2.56# | 71.19±5.55# | 71.88±2.13# | 72.20±2.18# | 65.78±6.51# | 69.24±12.03 |
NC, normal control; OAC, osteoarthritis control; YOBH, Yeonsan Ogye bone hydrolysate (500, 1,000, 2,000 mg/kg/day); MIA, monosodium iodoacetate.
All values are mean±SD (n=6).
Statistical significance was determined by one-way ANOVA followed by Dunnett’s post hoc test. *p<0.05 compared to NC group; #p<0.05 compared to OAC group.