Table 3. Effects of YOBH on hindlimb weight-bearing distribution in MIA-induced osteoarthritis rats

Group Hindlimb weight-bearing distribution (%)
Days after MIA injection
7 12 17 22 27 32
NC1) 100.00±7.572) 100.00±7.90 100.00±4.47 100.00±3.88 100.00±3.34 100.00±1.64
OAC 52.90±6.07*3) 59.29±3.83* 59.62±5.04* 59.74±6.15* 54.21±5.72* 57.19±7.74*
YOBH 500 54.35±11.14 58.62±14.70 59.15±11.15 62.35±13.21 58.93±12.32 62.36±9.03
YOBH 1,000 59.60±5.62 65.36±5.38#2) 67.87±4.42# 69.04±4.41# 70.12±5.70# 66.77±12.61
YOBH 2,000 62.53±2.56# 71.19±5.55# 71.88±2.13# 72.20±2.18# 65.78±6.51# 69.24±12.03
NC, normal control; OAC, osteoarthritis control; YOBH, Yeonsan Ogye bone hydrolysate (500, 1,000, 2,000 mg/kg/day); MIA, monosodium iodoacetate.
All values are mean±SD (n=6).
Statistical significance was determined by one-way ANOVA followed by Dunnett’s post hoc test. *p<0.05 compared to NC group; #p<0.05 compared to OAC group.