Table S2. Independent variables used in the response surface design and their levels

Independent Variables	Symbol	Coded Variables levels
		−2	−1	0	+1	+2
Time (min)	X1	120	150	180	210	240
Enzyme concentration (mg/mL)	X2	0.5	1	1.5	2	2.5
pH	X3	7	7.5	8	8.5	9