Table 3. Box-Behnken design and experimental data

Run	Variables			Responses
	Ethanol concentration X1 (%)	HCl concentration X2 (M)	Extraction time X3 (h)	Hesperetin (mg/g dry mass)
1	60	0	6	0.23±0.00
2	100	0	6	0.23±0.00
3	60	1	6	22.72±0.06
4	100	1	6	21.40±0.02
5	60	0.5	4	18.05±0.06
6	100	0.5	4	41.06±0.04
7	60	0.5	8	30.57±0.58
8	100	0.5	8	29.24±0.14
9	80	0	4	0.27±0.01
10	80	1	4	30.52±0.15
11	80	0	8	0.38±0.00
12	80	1	8	31.24±0.05
13	80	0.5	6	26.47±0.13
14	80	0.5	6	33.03±0.25
15	80	0.5	6	32.50±0.41