Table 3.
Inhibitory effects of the methanolic extract of A. asphodeloides and its n-hexane, EtOAc-, n-BuOH-, and H2O-soluble portions against pancreatic lipase
Conc. (mg/mL) | Inhibition (%)1) | IC50 (mg/ml) |
1000 | 500 | 250 | 125 | 62.5 | 31.3 |
70% MeOH ext. | 74.3 | 82.6 | 54.6 | 44.2 | 46.7 | -3) | 167.2±46.7 |
n-Hexane layer | - | - | - | - | - | - | >1000 |
EtOAc layer | 87.4 | 83.1 | 80.1 | 77.1 | 72.4 | 50.4 | 31.3±0.1 |
n-BuOH layer | 72.4 | 32.3 | 25.6 | 13.8 | 1.7 | 19.6 | 673.7±96.5 |
H2O layer | 86.7 | 86.7 | 76.7 | 50.4 | 46.2 | 45,7 | 90.1±14.7 |
Orlistat2) | 100 | 100 | 100 | 92.2 | 92.7 | 91.8 | 0.2±0.1 |
Data represent the mean±SD three replications.
Orlistat was used as a positive control.
Not detected